The vitamins that I took didn't make any difference to my migraines in the end. I went to the National Migraine clinic and they think I have medication over-use (too many pain killers and Maxalts) which causes constant rebound migraines because I can't fight the pain off anymore. The only way to over come this is to not take any pain killers for a while (complete cold-turkey for a couple of months wahhh!) wish me luck!